Best Computer Mouse for Large Hands Updated May 2025

Join the millions that have trusted BuyersGuide.org to help them make smarter buying decisions. Let our independent expert reviews and data-driven shopping recommendations help you find the one that's right for you.

Best Computer Mouse for Large Hands
2025 Buyer's GuideUpdated May 2025
Sort by:

10.0

1

10.0

ProtoArc Wireless Trackball Mouse, EM01 NL Ergonomic Bluetooth Rollerball Thumb Rechargeable Computer Laptop Mouse, Adjustable ...
Comfort
Functionality
Value for money
Mouse quality
Build quality
Connectivity
Picked by 305 people this week!
Picked by 305 people this week!

10.0

1
ProtoArc Wireless Trackball Mouse, EM01 NL Ergonomic Bluetooth Rollerball Thumb Rechargeable Computer Laptop Mouse, Adjustable ...
Comfort
Functionality
Value for money
Mouse quality
Build quality
Connectivity

9.8

2

9.8

Redragon M612 Predator RGB Gaming Mouse, 8000 DPI Wired Optical Mouse with 11 Programmable Buttons & 5 Backlit Modes, Software ...
Mouse quality
Value for money
Comfort
Looks
Responsiveness
Color modes

9.8

2
Redragon M612 Predator RGB Gaming Mouse, 8000 DPI Wired Optical Mouse with 11 Programmable Buttons & 5 Backlit Modes, Software ...
Mouse quality
Value for money
Comfort
Looks
Responsiveness
Color modes

9.6

3

9.6

Redragon M908 Impact RGB LED MMO Gaming Mouse with 12 Side Buttons, Optical Wired Ergonomic Mouse with Max 12,400DPI, High Prec...
Gaming performance
Comfort
Value for money
Ease of use
Design

9.6

3
Redragon M908 Impact RGB LED MMO Gaming Mouse with 12 Side Buttons, Optical Wired Ergonomic Mouse with Max 12,400DPI, High Prec...
Gaming performance
Comfort
Value for money
Ease of use
Design

9.5

4

9.5

ProtoArc Ergonomic Mouse, EM11 NL Bluetooth Rechargeable Wireless Vertical Mouse, 3 Multi-Device Connectivity for Computer/PC/L...
Comfort
Functionality
Value for money
Design
Click quality
Mouse quality

9.5

4
ProtoArc Ergonomic Mouse, EM11 NL Bluetooth Rechargeable Wireless Vertical Mouse, 3 Multi-Device Connectivity for Computer/PC/L...
Comfort
Functionality
Value for money
Design
Click quality
Mouse quality

9.4

5

9.4

Redragon M810 Pro Wireless Gaming Mouse, 10000 DPI Wired/Wireless Gamer Mouse w/Rapid Fire Key, 8 Macro Buttons, 45-Hour Reliab...
Mouse quality
Functionality
Feel
Value for money
Looks
Responsiveness

9.4

5
Redragon M810 Pro Wireless Gaming Mouse, 10000 DPI Wired/Wireless Gamer Mouse w/Rapid Fire Key, 8 Macro Buttons, 45-Hour Reliab...
Mouse quality
Functionality
Feel
Value for money
Looks
Responsiveness

9.3

6

9.3

Lekvey Ergonomic Mouse, Vertical Wireless Mouse - Rechargeable 2.4GHz Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Le...
Comfort
Quality
Ease of use
Design
Value for money

9.3

6
Lekvey Ergonomic Mouse, Vertical Wireless Mouse - Rechargeable 2.4GHz Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Le...
Comfort
Quality
Ease of use
Design
Value for money

9.1

7

9.1

E-YOOSO Wireless Mouse, 2.4G USB Computer Mouse with 5 Levels 4000 DPI, 18 Months Battery Life, Ergonomic Grips, 6 Buttons Larg...
Reliability
Size
Comfort
Value for money
Ease of use
Functionality

9.1

7
E-YOOSO Wireless Mouse, 2.4G USB Computer Mouse with 5 Levels 4000 DPI, 18 Months Battery Life, Ergonomic Grips, 6 Buttons Larg...
Reliability
Size
Comfort
Value for money
Ease of use
Functionality

8.9

8

8.9

Logitech Signature M550 L Full Size Wireless Mouse - for Large Sized Hands, 2-Year Battery, Silent Clicks, Bluetooth, Multi-Dev...
Mouse quality
Size
Functionality
Noise level
Comfort
Bluetooth connectivity

8.9

8
Logitech Signature M550 L Full Size Wireless Mouse - for Large Sized Hands, 2-Year Battery, Silent Clicks, Bluetooth, Multi-Dev...
Mouse quality
Size
Functionality
Noise level
Comfort
Bluetooth connectivity

8.8

9

8.8

Logitech Wireless Mouse Signature M650 L Full Size - Large Hands, 2-Year Battery, Silent Clicks, Customizable Buttons, Bluetoot...
Quietness
Functionality
Mouse quality
Size
Comfort
Bluetooth connectivity

8.8

9
Logitech Wireless Mouse Signature M650 L Full Size - Large Hands, 2-Year Battery, Silent Clicks, Customizable Buttons, Bluetoot...
Quietness
Functionality
Mouse quality
Size
Comfort
Bluetooth connectivity

8.7

10

8.7

E-YOOSO Large Wireless Mouse for Big Hands, X-31 Cordless Ergo Computer Mouse, 6 Buttons, 5-Level 4800 DPI, 18 Months Battery L...
Fit
Comfort
Mouse quality
Ease of use
Value for money

8.7

10
E-YOOSO Large Wireless Mouse for Big Hands, X-31 Cordless Ergo Computer Mouse, 6 Buttons, 5-Level 4800 DPI, 18 Months Battery L...
Fit
Comfort
Mouse quality
Ease of use
Value for money

Our Top Choice

10.0

1

10.0

ProtoArc Wireless Trackball Mouse, EM01 NL Ergonomic Bluetooth Rollerball Thumb Rechargeable Computer Laptop Mouse, Adjustable ...
Comfort
Functionality
Value for money
Mouse quality
Build quality
Connectivity
Picked by 305 people this week!
Picked by 305 people this week!

10.0

1
ProtoArc Wireless Trackball Mouse, EM01 NL Ergonomic Bluetooth Rollerball Thumb Rechargeable Computer Laptop Mouse, Adjustable ...
Comfort
Functionality
Value for money
Mouse quality
Build quality
Connectivity