Best Cold Sore Medicines Updated May 2025
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Best Cold Sore Medicines
2025 Buyer's GuideUpdated May 2025
Advertiser disclosure About our rankings
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Best Cold Sore Medicine

10.0

1

10.0

Acculip Cold Sore Patch Lysine Cold Sore Treatment for Lips, Lysine Lip Balm Alternative for Cold Sore Relief, Medicated Fever ...
Pain relief
Effectiveness
Value for money
20% Coupon
Picked by 238 people this week!
20% Coupon
Picked by 238 people this week!
Picked by 238 people this week!
Best Cold Sore Medicine

10.0

1
Acculip Cold Sore Patch Lysine Cold Sore Treatment for Lips, Lysine Lip Balm Alternative for Cold Sore Relief, Medicated Fever ...
Pain relief
Effectiveness
Value for money
Picked by 238 people this week!
20% Coupon

9.7

2

9.7

FemiClear for Genital Herpes Symptoms & Cold Sores, Multi-Symptom - Effective Intimate Relief - Made with All-Natural and Organ...
Functionality
Relief
Speed

9.7

2
FemiClear for Genital Herpes Symptoms & Cold Sores, Multi-Symptom - Effective Intimate Relief - Made with All-Natural and Organ...
Functionality
Relief
Speed

9.5

3

9.5

Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams
Functionality
20% Coupon
20% Coupon

9.5

3
Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams
Functionality
20% Coupon

9.4

4

9.4

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2
Value for money
Works well
Effectiveness
Healing time
Save 26% + 20% Coupon
Save 26% + 20% Coupon

9.4

4
Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2
Value for money
Works well
Effectiveness
Healing time
Save 26% + 20% Coupon

9.3

5

9.3

Advanced Lysine Immune Boost 975 mg with Zinc, Echinacea, Vitamin C - Maximum Immune Support Supplement - Lysine Outbreak Suppo...
Effectiveness
Immune support
Ease of swallow
Energy boost
Cold sores
Stomach irritation
$6 Coupon
$6 Coupon

9.3

5
Advanced Lysine Immune Boost 975 mg with Zinc, Echinacea, Vitamin C - Maximum Immune Support Supplement - Lysine Outbreak Suppo...
Effectiveness
Immune support
Ease of swallow
Energy boost
Cold sores
Stomach irritation
$6 Coupon
Popular

9.1

6

9.1

Beekeeper's Naturals Propolis Throat Spray, Natural Immune Support & Sore Throat Relief - Antioxidants, Keto, Paleo, Gluten-Fre...
Functionality
Throat relief
Immune support
Ease of use
Popular

9.1

6
Beekeeper's Naturals Propolis Throat Spray, Natural Immune Support & Sore Throat Relief - Antioxidants, Keto, Paleo, Gluten-Fre...
Functionality
Throat relief
Immune support
Ease of use
Premium Pick

9.0

7

9.0

Cold Sore Treatment for Lips - Lysine Supercharged with Acidophilus Probiotic & Lactobacillus Rhamnosus + Vitamin C for Lip and...
Immune health
Functionality
Digestion
Premium Pick

9.0

7
Cold Sore Treatment for Lips - Lysine Supercharged with Acidophilus Probiotic & Lactobacillus Rhamnosus + Vitamin C for Lip and...
Immune health
Functionality
Digestion

8.9

8

8.9

Lyranda® - Lysine Cold Sore Treatment - Chewable L-Lysine Tablets - Faster Absorption and Better Hygiene
Effectiveness

8.9

8
Lyranda® - Lysine Cold Sore Treatment - Chewable L-Lysine Tablets - Faster Absorption and Better Hygiene
Effectiveness

8.8

9

8.8

Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicato...
Pain relief
Works well
Value for money
Healing time
Evaporation time

8.8

9
Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicato...
Pain relief
Works well
Value for money
Healing time
Evaporation time
Best Value

8.7

10

8.7

Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand
Pain relief
Works well
Value for money
Ease of application
Gel consistency
Save 27%
Save 27%
Best Value

8.7

10
Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- From #1 Oral Pain Relief Brand
Pain relief
Works well
Value for money
Ease of application
Gel consistency
Save 27%

Our Top Choice

Best Cold Sore Medicine

10.0

1

10.0

Acculip Cold Sore Patch Lysine Cold Sore Treatment for Lips, Lysine Lip Balm Alternative for Cold Sore Relief, Medicated Fever ...
Pain relief
Effectiveness
Value for money
20% Coupon
Picked by 238 people this week!
20% Coupon
Picked by 238 people this week!
Picked by 238 people this week!
Best Cold Sore Medicine

10.0

1
Acculip Cold Sore Patch Lysine Cold Sore Treatment for Lips, Lysine Lip Balm Alternative for Cold Sore Relief, Medicated Fever ...
Pain relief
Effectiveness
Value for money
Picked by 238 people this week!
20% Coupon
Related Categories
Medicine for ColdsLip Scar TreatmentDecongestant for High Blood PressureThroat Spray for SingersCarb BlockerChill Pill
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Related Categories
Medicine for ColdsLip Scar TreatmentDecongestant for High Blood PressureThroat Spray for SingersCarb BlockerChill Pill
Related Categories
Medicine for ColdsLip Scar TreatmentDecongestant for High Blood PressureThroat Spray for SingersCarb BlockerChill Pill