Best Bed Bug Sprays for Mattresses Updated May 2025
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Best Bed Bug Sprays for Mattresses
2025 Buyer's GuideUpdated May 2025
Advertiser disclosure About our rankings
Sort by:
Best Overall

10.0

1

10.0

Eco Defense Bed Bug Killer - Bed Bug Spray & Dust Mite Spray - Natural Treatment - 16 oz
Works well
Kills bugs
Safety
Kills on contact
Ease of use
Picked by 111 people this week!
Picked by 111 people this week!
Picked by 111 people this week!
Best Overall

10.0

1
Eco Defense Bed Bug Killer - Bed Bug Spray & Dust Mite Spray - Natural Treatment - 16 oz
Works well
Kills bugs
Safety
Kills on contact
Ease of use
Picked by 111 people this week!
Premium Pick

9.8

2

9.8

BugMD Ant Killer & Bug Spray - Roach and Cockroach Killer Indoor, Spider Spray for Home, Fly and Insect Defense, Natural, Safe ...
Smell
Safety for pets
Effectiveness
Ease of use
Quality
Save 33% + 21% Coupon
Save 33% + 21% Coupon
Premium Pick

9.8

2
BugMD Ant Killer & Bug Spray - Roach and Cockroach Killer Indoor, Spider Spray for Home, Fly and Insect Defense, Natural, Safe ...
Smell
Safety for pets
Effectiveness
Ease of use
Quality
Save 33% + 21% Coupon

9.5

3

9.5

Bed Bug Patrol Natural Bed Bug Killer Spray – 24oz Bottle – Non-Toxic Formula, Safe for Children and Pets – Ideal for Home, Off...
Effectiveness
Smell
Kills bugs
Safety for pets
Spray effectiveness
Ease of use
Save 5% + 8% Coupon
Save 5% + 8% Coupon

9.5

3
Bed Bug Patrol Natural Bed Bug Killer Spray – 24oz Bottle – Non-Toxic Formula, Safe for Children and Pets – Ideal for Home, Off...
Effectiveness
Smell
Kills bugs
Safety for pets
Spray effectiveness
Ease of use
Save 5% + 8% Coupon

9.4

4

9.4

Premo Guard Bed Bug Killer Spray 24 oz - University Tested 100% Kill Rate - Natural Non Toxic, Stain & Scent Free - Kill Bedbug...
Effectiveness
Kills bugs
Scent
Safety
Ease of use
5% Coupon
5% Coupon

9.4

4
Premo Guard Bed Bug Killer Spray 24 oz - University Tested 100% Kill Rate - Natural Non Toxic, Stain & Scent Free - Kill Bedbug...
Effectiveness
Kills bugs
Scent
Safety
Ease of use
5% Coupon

9.3

5

9.3

Bed Bug Patrol Natural Bed Bug Travel Spray – 3oz TSA Approved Bottle – Non-Toxic, Plant-Based & Child Safe – for Hotels, Airbn...
Effectiveness
Scent
Carryability
Peace of mind
Safety
Kills bugs
Save 20% + 8% Coupon
Save 20% + 8% Coupon

9.3

5
Bed Bug Patrol Natural Bed Bug Travel Spray – 3oz TSA Approved Bottle – Non-Toxic, Plant-Based & Child Safe – for Hotels, Airbn...
Effectiveness
Scent
Carryability
Peace of mind
Safety
Kills bugs
Save 20% + 8% Coupon
Popular

9.2

6

9.2

Sawyer Products SP657 Premium Permethrin Insect Repellent for Clothing, Gear & Tents, Trigger Spray, 24-Ounce
Effectiveness
Bugs repellent
Tick resistance
Ease of application
Longevity
Tick protection
Popular

9.2

6
Sawyer Products SP657 Premium Permethrin Insect Repellent for Clothing, Gear & Tents, Trigger Spray, 24-Ounce
Effectiveness
Bugs repellent
Tick resistance
Ease of application
Longevity
Tick protection
Best Value

9.1

7

9.1

Nix Lice & Bedbug Killing Spray for Home, Bedding & Furniture, 5 fl oz
Effectiveness
Kills lice
30% Coupon
30% Coupon
Best Value

9.1

7
Nix Lice & Bedbug Killing Spray for Home, Bedding & Furniture, 5 fl oz
Effectiveness
Kills lice
30% Coupon

9.0

8

9.0

Bed Bug Killer 16 oz EcoVenger by EcoRaider, 100% Kill Efficacy, Bedbugs & Mites, Kills Eggs & The Resistant, Lasting Protectio...
Effectiveness
Kills bugs
Safety for pets
Ease of use
Kills quickly

9.0

8
Bed Bug Killer 16 oz EcoVenger by EcoRaider, 100% Kill Efficacy, Bedbugs & Mites, Kills Eggs & The Resistant, Lasting Protectio...
Effectiveness
Kills bugs
Safety for pets
Ease of use
Kills quickly

8.9

9

8.9

Ortho Home Defense Max Bed Bug, Flea and Tick Killer with Comfort Wand, Bed Bug Spray, Kills Bed Bug Eggs, Fleas and Ticks, 1 g...
Effectiveness
Smell
Ease of use
Save 13%
Save 13%

8.9

9
Ortho Home Defense Max Bed Bug, Flea and Tick Killer with Comfort Wand, Bed Bug Spray, Kills Bed Bug Eggs, Fleas and Ticks, 1 g...
Effectiveness
Smell
Ease of use
Save 13%

8.7

10

8.7

Raid Bed Bug Foaming Spray, Kills Bed Bugs and Their Eggs, for Indoor Use, Non-Staining, Keeps Killing for Weeks, 16.5 oz (Pack...
Effectiveness
Value for money
Kills bed bugs
Scent
Ease of use
Kills insects

8.7

10
Raid Bed Bug Foaming Spray, Kills Bed Bugs and Their Eggs, for Indoor Use, Non-Staining, Keeps Killing for Weeks, 16.5 oz (Pack...
Effectiveness
Value for money
Kills bed bugs
Scent
Ease of use
Kills insects

Our Top Choice

Best Overall

10.0

1

10.0

Eco Defense Bed Bug Killer - Bed Bug Spray & Dust Mite Spray - Natural Treatment - 16 oz
Works well
Kills bugs
Safety
Kills on contact
Ease of use
Picked by 111 people this week!
Picked by 111 people this week!
Picked by 111 people this week!
Best Overall

10.0

1
Eco Defense Bed Bug Killer - Bed Bug Spray & Dust Mite Spray - Natural Treatment - 16 oz
Works well
Kills bugs
Safety
Kills on contact
Ease of use
Picked by 111 people this week!
Related Categories
Bed Bug KillerBed Bug SprayBed Bug FoggerBed Bugs RepellentSpider Killer SprayHome Insecticide
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Related Categories
Bed Bug KillerBed Bug SprayBed Bug FoggerBed Bugs RepellentSpider Killer SprayHome Insecticide
Related Categories
Bed Bug KillerBed Bug SprayBed Bug FoggerBed Bugs RepellentSpider Killer SprayHome Insecticide